Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Spinal cord injury
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 10
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Efficacy of Allogenic Bone Marrow Stem Cells Transplantation in Patients With Liver Failure Resulting From Chronic Hepatitis B
Liver Failure
Enrolment: 60 · Results not recorded
Dose Escalation Phase II Study of Intraarterial Ex-vivo Cultured Adult Allogenic Mesenchymal Stem Cells in Alcoholic Liver Cirrhosis
Alcoholic Liver Cirrhosis
Enrolment: 40 · Results not recorded
The Efficacy of Allogenic Bone Marrow Stem Cells Transplantation in Patients With Liver Cirrhosis Resulting From Chronic Hepatitis B
Liver Cirrhosis
Enrolment: 60 · Results not recorded
Biochemical Correction of Severe Epidermolysis Bullosa by Allogeneic Cell Transplantation and Serial Donor Mesenchymal Cell Infusions
Epidermolysis Bullosa
Enrolment: 17 · Results not recorded
Treatment of Knee Osteoarthritis With Allogenic Mesenchymal Stem Cells (MSV)
Osteoarthritis, Knee
Enrolment: 30 · Results not recorded
A Phase IB/IIA Study of Adult Allogeneic Bone Marrow Derived Mesenchymal Stem Cells for Rectovaginal Fistulas in Crohn's Disease
Rectovaginal Fistula · Crohn Disease
Enrolment: 20 · Results not recorded
A Phase IB/IIA Study of Remestemcel-L (Allogeneic BM-MSC) for Medically Refractory Crohn's Colitis
Crohn Colitis
Enrolment: 7 · Results not recorded
A Phase 1 Study of VELGRAFT, a Living Cellular Construct Containing Human Bone Marrow-derived MSCs, in Chronic Diabetic Foot Ulcers
Diabetic Foot Ulcer (DFU)
Enrolment: 24 · Results not recorded
Phase 1 Study: Treatment of Patients With Diabetic Foot Complications With Allogeneic Bone Marrow Derived Mesenchymal Stromal Cells
Type I Diabetes Mellitus With Ulcer · Type II Diabetes Mellitus With Ulcer
Enrolment: 12 · Results not recorded
A Phase 1 Study to Evaluate the Safety of CS20AT04 Inj. (allogenic BM-MSC) in Subjects With Lupus Nephritis
Lupus Nephritis
Enrolment: 7 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatSpinal cord injuryContusionSprague-DawleyMalen = 48 rats, 12 per group (4 for histology and 8 for biochemica…Intralesional injection into the injured cord with a 26-gauge Hamilton needle, or scaffold applied to the dorsal surface of the injured cord10 microlitre cell suspension per animal for intralesional…Immediately after the contusive injury (acute spinal cord injury)
Model: Contusive spinal cord injury at T9 after T8-10 laminectomy, 25 g-cm contusion with the MASCIS impactor (10 g rod dropped from 2.5 cm)
Scaffold-based delivery gave higher mesenchymal stem cell engraftment (25.6 plus or minus 1.7 for PLGA and 26.7 plus or minus 1.8 for chitosan versus 20.6 plus or minus 0.7 cells per high power field for intralesional injection) and favoured oligodendrocytic over astrocytic differentiation. BDNF an…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.