THERAPY DOSSIER · th-390eccd924ec

Human bone marrow-derived stromal cells prepared by negative selection

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01557543 ↗PHASE1terminated

Preliminary Assessment of Direct Intra-Myocardial Injection of Autologous Bone Marrow-derived Stromal Cells on Patients Undergoing Revascularization for CAD With Depressed Left Ventricular Function

Heart Disease · Ischemic Heart Disease · Coronary Artery Disease

Enrolment: 24 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32066435 ↗2020Mixed findings

Treatment of rats with spinal cord injury using human bone marrow-derived stromal cells prepared by negative selection.

RatSpinal cord injuryContusionMaleSub-occipital injection into the cisterna magnaOn average 2.3 million non-manipulated cells in 100 microli…One hour after lesion

Model: Spinal cord contusion injury at thoracic level T9/T10 using the Infinite Horizon impactor

Rats did not reject the human implants and showed no sickness behaviour or neuropathic pain. Compared with methylprednisolone, treated animals showed better recovery of motor deficits, with no difference in bladder control. Histology at ten weeks showed no difference in tissue sparing or astroglios…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

Loading the evidence…