Sulforhodamine B interacts with albumin to lower surface tension and protect against ventilation injury of flooded alveoli.
RatOtherSprague-DawleyMaleAlveolar instillation by micropunctureInstilled with the albumin flooding solution before ventilation
Model: Isolated perfused lung with micropuncture instillation of albumin solution producing heterogeneous alveolar flooding, then injurious mechanical ventilation
Addition of rhodamine dye lowered surface tension, reduced ventilation-induced injury and facilitated liquid escape from flooded alveoli in the isolated rat lung, and the dye was directly surface active in albumin solution in vitro.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.