Chrysophyllum cainito leaves are effective against pre-clinical chronic pain models: Analysis of crude extract, fraction and isolated compounds in mice.
MouseOtherFemale
Model: Post-operative (plantar incision) pain, complete Freund's adjuvant chronic inflammatory pain, and two neuropathic pain models; acute inflammatory hypersensitivity induced by PGE2, epinephrine, LPS or CFA
The crude methanol extract reduced mechanical hypersensitivity induced by PGE2, epinephrine, LPS and CFA and, on repeated dosing, raised withdrawal thresholds in post-operative, chronic inflammatory and two neuropathic pain models. The chloroform fraction was most active in the neuropathic models,…
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.