Hepatoprotective standardized EtOH-water extract from the seeds of Fraxinus rhynchophylla Hance.
MouseChemical/toxinKunmingMalen = 5 groups of 12 animals each, 60 totalIntragastric2.0 g/kg and 4.0 g/kg body weightPretreatment for 7 weeks before the carbon tetrachloride challenge
Model: Carbon tetrachloride in peanut oil (0.1:100, 0.1 mL/10 g) given on day 49, two hours after the last extract dose
Pretreatment with the seed extract lowered serum transaminases and hepatic malondialdehyde, raised antioxidant enzyme activity and reduced histological liver damage after carbon tetrachloride.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.