Zerumbone attenuates the severity of acute necrotizing pancreatitis and pancreatitis-induced hepatic injury.
RatChemical/toxinWistarMalen = Preliminary study 8 per group; formal study taurocholate an…Intravenous via femoral vein10 mg/kg, selected from a preliminary dose-ranging study of…30 minutes before induction of pancreatitis (pretreatment)
Model: Acute necrotizing pancreatitis induced by retrograde biliary-pancreatic duct infusion of 5% sodium taurocholate, with secondary hepatic injury
Zerumbone pretreatment significantly reduced serum amylase, sPLA2, ALT and AST and improved pancreatic and hepatic histopathology, inhibited NF-kappaB and downregulated ICAM-1 and IL-1beta mRNA. In the preliminary study neither 5 nor 40 mg/kg improved sPLA2 and ALT, and 10 mg/kg was the minimum eff…
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