THERAPY DOSSIER · th-31e511a4a04b

Olfactory lamina propria containing olfactory ensheathing cells, or respiratory lamina propria without olfactory ensheathing cells

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03933072 ↗Injury indicationPHASE1/PHASE2unknown

Functional axon regeneration using autologous bulbar olfactory ensheathing cells and spinal cord bridging in complete spinal cord injury

Spinal Cord Injury at C5-Th10 Level With Complete Lesion · Spinal Cord Transection

Enrolment: 2 · Results not recorded

NCT01231893 ↗Injury indicationPHASE1unknown

Transplantation of autologous olfactory ensheathing cells for treatment of complete human spinal cord injuries

Complete Spinal Cord Injuries

Enrolment: 10 · Results not recorded

NCT02870426 ↗Injury indicationPhase not recordedunknown

Collection and characterisation of human olfactory ensheathing cells

Spinal Cord Injury

Enrolment: 50 · Results not recorded

NCT01327768 ↗PHASE1unknown

Safety and feasibility of intracerebral implantation of olfactory ensheathing cells in old stroke patients

Infarction, Middle Cerebral Artery · Ischemic Stroke

Enrolment: 6 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22041228 ↗2011Mixed findings

Olfactory and respiratory lamina propria transplantation after spinal cord transection in rats: effects on functional recovery and axonal regeneration.

RatSpinal cord injuryComplete transectionWistarMaleTransplantation of tissue pieces into the lesion siteAcute, 2 weeks or 4 weeks after injury

Model: Complete spinal cord transection

Both graft types produced only discrete and comparable hindlimb improvement with similar tissue sparing and sprouting, acute grafting fostered limited supraspinal regeneration, and no differences were found between acute, 2 week or 4 week delayed transplantation, suggesting the effects were not att…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.

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