THERAPY DOSSIER · th-30e404d51832

TNF-related apoptosis-inducing ligand (TRAIL)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24771425 ↗2014Reported benefit

Systemic effects of TRAIL (TNF-related apoptosis-inducing ligand) during acute gamma-irradiation.

MouseRadiation101/Hf and C3H/SnMaleIntravenous injection

Model: Acute whole-body gamma irradiation at 750 R

TRAIL attenuated irradiation-induced changes in body weight, plasma subfractions, open field activity, intestinal and hepatic tissue injury and thymic Hassall's corpuscle content, with the degree of change differing between the two mouse strains.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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