Neutralization of inhibitory molecule NG2 improves synaptic transmission, retrograde transport, and locomotor function after spinal cord injury in adult rats.
RatSpinal cord injuryHemisection / partialSprague-DawleyFemaleAcute intraspinal injection for conduction experiments; chronic intrathecal infusion for the chronic treatment experimentsAcute intraspinal injections at the time of NG2 exposure; chronic intrathecal i…
Model: Chronic midthoracic lateral hemisection of the spinal cord; acute intraspinal NG2 application used to test conduction block
Acute intraspinal anti-NG2 antibody prevented the acute NG2-induced block of axonal conduction, and chronic intrathecal infusion after midthoracic lateral hemisection improved synaptic transmission to lumbar motoneurons, retrograde tracer transport from L5 to L1 and CatWalk locomotor function. Trea…
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