THERAPY DOSSIER · th-2eadcbf4b122

Blue light at 415 nm

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Burn
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07042659 ↗Injury indicationNAcompleted

Accelerated photobiomodulation protocol with blue light in patients with hard-to-heal wounds

Hard-to-heal Wounds · Chronic Wounds · Wound Healing Delayed · Photobiomodulation Therapy

Enrolment: 11 · Results not recorded

NCT05739058 ↗Injury indicationNAcompleted

Violet-blue light inactivation of bacteria in chronic wounds (FlashHeal device)

Phototherapy Complication · Photobiology · Wound Infection · Wound Heal

Enrolment: 22 · Results not recorded

NCT04300010 ↗PHASE4completed

Efficacy of blue light therapy in reducing Cutibacterium acnes bioburden at the deltopectoral interval

Acne

Enrolment: 60 · Results not recorded

NCT01689935 ↗PHASE1completed

Pilot trial to reduce side-effects of photodynamic therapy for moderate to severe acne (blue light only arm)

Acne Vulgaris

Enrolment: 35 · Results not recorded

NCT02924428 ↗NAterminated

Venus Versa Diamonpolar applicator followed by AC dual applicator using two intense pulsed light wavelength bands for facial acne vulgaris

Acne Vulgaris

Enrolment: 47 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23262998 ↗2012Reported benefit

Blue light rescues mice from potentially fatal Pseudomonas aeruginosa burn infection: efficacy, safety, and mechanism of action.

MouseBurnUnspecifiedBALB/cFemaleTopical illumination of the infected burn55.8 J/cm230 min after bacterial inoculation

Model: Burn wound inoculated with Pseudomonas aeruginosa

A single blue light exposure reduced the area under the bioluminescence time curve approximately 100-fold compared with untreated infected burns (p < 0.0001) and increased survival from 18.2% to 100% (p < 0.0001), with no significant histological skin damage at the effective dose.

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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