CD51 distinguishes a subpopulation of bone marrow mesenchymal stem cells with distinct migratory potential: a novel cell-based strategy to treat acute myocardial infarction in mice.
MouseIschaemia-reperfusionCardiacC57BL/6J recipients; bone marrow donor cells from 14-day-old C57BL/6 miceMalen = 60 male C57BL/6J mice purchased for the study; two mice die…Intravenous, tail vein injection of cells suspended in 500 microlitres of saline30 min after myocardial infarction per the Methods; the abstract states immedia…
Model: Acute myocardial infarction produced by permanent ligation of the left anterior descending coronary artery approximately 0.3 cm from its origin, with a sham-operated comparison group
CD51-positive cells outperformed CD51-negative cells after intravenous delivery. Left ventricular ejection fraction was 53.2 plus or minus 5.4% versus 28.9 plus or minus 4.1% and fractional shortening 26.6 plus or minus 3.5% versus 13.5 plus or minus 2.0%. Infarct area as a proportion of left ventr…
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