THERAPY DOSSIER · th-2973104511a7

Preoperative fasting (food deprivation)

Other

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05760339 ↗NArecruiting

Preoperative Intermittent Fasting Versus Carbohydrate Loading to Reduce Insulin Resistance: a Randomised Controlled Trial

Perioperative Care · Intermittent Fasting · Insulin Resistance

Enrolment: 75 · Results not recorded

NCT04664751 ↗NAcompleted

Incidence of Compliance to the ASA Preoperative Fasting Guidelines in Elective General Surgery

Compliance, Treatment

Enrolment: 309 · Results not recorded

NCT06915493 ↗NAcompleted

Blood Glucose Levels in Children During Anesthesia: Incidence of Hypoglycemia and Its Relationship to Preoperative Fasting

Fasting

Enrolment: 350 · Results not recorded

NCT06105866 ↗NAenrolling by invitation

Relationship of Preoperative Fasting With Tricuspid Annular Plane Systolic Excursion (TAPSE)

Volume status

Enrolment: 100 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30818054 ↗2019Reported benefit

Fasting reduces oxidative stress, mitochondrial dysfunction and fibrosis induced by renal ischemia-reperfusion injury.

RatIschaemia-reperfusionRenaldietary intervention3 days of food deprivation3 days preoperatively

Model: Acute renal ischaemia-reperfusion injury

Three days of preoperative fasting protected against tubular damage and renal functional decline, preserved mitochondrial morphology and function and limited long-term tubulointerstitial fibrosis.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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