Novel anti-microbial peptide SR-0379 accelerates wound healing via the PI3 kinase/Akt/mTOR pathway.
RatWoundCrl:CD(SD)Malen = 4 to 5 rats per group in the disc implantation experiments;…Topical to the wound; subcutaneous implantation for the disc model0.2 mg/ml in 50 microlitres for the diabetic flap model; 1…From the time of wounding, with bacteria applied on days 0 to 3 in the infected…
Model: Full-thickness skin defect with flap in streptozotocin-induced diabetic rats; full-thickness wound inoculated with Staphylococcus aureus in cyclophosphamide-treated rats; incised wound and paper disc implantation models
SR-0379 significantly accelerated wound closure compared with fibroblast growth factor 2 in both the diabetic flap model and the Staphylococcus aureus-infected full-thickness model, with enhanced angiogenesis, granulation tissue formation and proliferation of endothelial cells and fibroblasts along…
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