Post-blast treatment with Nociceptin/Orphanin FQ peptide (NOP) receptor antagonist reduces brain injury-induced hypoxia and signaling proteins in vestibulomotor-related brain regions.
RatTBIBlast / overpressureSprague-Dawleymalesingle treatment administered post-blast
Model: single 80 psi head blast exposure, blast-induced mild TBI
A single post-blast dose of the NOP receptor antagonist SB-612111 transiently improved acute vestibulomotor performance and prevented increases in markers of TBI-induced hypoxia and pro-apoptotic injury proteins seen 8-10 days after blast TBI in rats.
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