Sinapic Acid Ameliorates Oxidative Stress, Inflammation, and Apoptosis in Acute Doxorubicin-Induced Cardiotoxicity via the NF-kB-Mediated Pathway.
RatChemical/toxinWistarMalen = n=6 per group, 4 groups, 24 rats totalOral20 mg/kgStarted 4 days before doxorubicin; on the doxorubicin day given 1 h after the i…
Model: Acute doxorubicin cardiotoxicity, single 15 mg/kg intraperitoneal dose on day 5, endpoint 48 h later
Sinapic acid 20 mg/kg reduced lactate dehydrogenase by 65.33 percent and creatine kinase-MB by 38.07 percent, lowered malondialdehyde and endothelin-1, restored superoxide dismutase, glutathione and catalase, reduced TNF-alpha, IL-1beta and myeloperoxidase, downregulated NF-kappaB p65, Bax and casp…
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