THERAPY DOSSIER · th-27a1768f130a

AgiCoat and Acticoat nanosilver dressings

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Burn
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02108535 ↗Injury indicationPHASE4completed

Comparative Analysis of Cost-effectiveness of Silver Dressing in Burns (nanocrystalline silver vs silver sulfadiazine)

Second-degree Burn

Enrolment: 100 · Results not recorded

NCT02852148 ↗Injury indicationNAcompleted

Prospective, Non-comparative, Multicentre Study to Evaluate a Silver Coated Antimicrobial Barrier Wound Dressing (ACTICOAT) in Burns and Chronic Wounds

Wounds and Injuries · Burns · Pressure Ulcer · Foot Ulcer

Enrolment: 25 · Results not recorded

NCT02577900 ↗NAcompleted

Randomized, Controlled Study of Nanocrystalline Silver, Manuka Honey and Conventional Dressing in Healing Diabetic Foot Ulcer

Diabetic Foot

Enrolment: 31 · Results not recorded

NCT03621592 ↗NAcompleted

Exploratory Trial of Dialkylcarbamoyl Chloride Dressing (Cutimed Sorbact) vs Acticoat in Modifying Bacterial Load in Venous Leg Ulcers

Venous Leg Ulcer

Enrolment: 31 · Results not recorded

NCT07521176 ↗NAcompleted

Evaluation of the Efficacy of Applying the Nano-crystalline Silver Membrane After Surgical Gingival Depigmentation

Gingival Pigmentation

Enrolment: 12 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31400763 ↗2020Mixed findings

Histopathological Changes of Organs (Lungs, Liver, Kidney, and Brain) After Using Two Types of AgiCoat and Acticoat Nanosilver Dressings on Deep Second-Degree Burn in Rat.

RatBurnUnspecifiedSprague-DawleyMalen = 24 rats, 12 per groupTopical dressingApplied after burn induction

Model: Deep second-degree dorsal skin burn produced by a standard method under anaesthesia

Serum silver rose significantly above the reference level with both dressings. Hepatotoxicity was greater with AgiCoat than Acticoat, no pathological change was seen in other organs, and wound healing was faster with Acticoat.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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