THERAPY DOSSIER · th-2777c11d3e5a

Glutathione, with taurine and L-carnitine as separate comparator agents, delivered by mesotherapy

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Burn · TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: Not recorded
ChEMBL max phase: 3 / 4 (development scale, not regulatory approval)
Synonyms: Glutathione; L-glutathione reduced; Tathione; NSC-400639; Aec glutathione
Note: Not recorded

Clinical trials 8

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00266331 ↗PHASE2completed

RayGel (reduced glutathione) versus placebo for skin care during external beam radiation

Breast Cancer

Enrolment: 150 · Results not recorded

NCT05371288 ↗EARLY_PHASE1withdrawn

Role of glutathione deficiency and MSIDS variables in long COVID-19

COVID-19

Enrolment: 0 · Results not recorded

NCT05926245 ↗PHASE1completed

Topical absorption of glutathione-cyclodextrin complex in healthy human subjects

Glutathione-cyclodextrin Complex Absorption

Enrolment: 30 · Results not recorded

NCT07379216 ↗Phase not recordedrecruiting

Efficacy evaluation of vitamin C and glutathione liquid sachet

Skin Condition · Anti-Oxidative Stress

Enrolment: 30 · Results not recorded

NCT02316925 ↗Phase not recordedwithdrawn

Oral glutathione supplementation on cold/flu symptoms in older healthy adults

Immune Cell Function in Elderly Humans

Enrolment: 0 · Results not recorded

NCT01402570 ↗Phase not recordedcompleted

Oral glutathione and health outcomes among persons with post-polio syndrome

Post-polio Syndrome · Physical Activity · Depression · Pain · Sleep Disorders

Enrolment: 20 · Results not recorded

NCT02321579 ↗Phase not recordedunknown

Vitamin B-6 and glutathione on inflammatory responses in liver cirrhosis or hepatocellular carcinoma

Liver Cirrhosis · Liver Cancer

Enrolment: 25 · Results not recorded

NCT07302828 ↗Phase not recordedcompleted

Effect of Double Nutri Liposomal Encapsulation Technology on Human Absorption of Vitamin C and Glutathione Liquid Sachet

Vitamin C · Glutathione

Enrolment: 20 · Results not recorded

Preclinical evidence 2

2 studies reported at therapy level; 2 evidence entries itemised.

PMID 26614529 ↗2015Reported benefit

Efficacy of glutathione mesotherapy in burns: an experimental study.

RatBurnUnspecifiedWistarMalen = 50 male Wistar rats in five groups of 10Intradermal injection into the reticular dermis using the point mesotherapy techniqueNot statedFirst course within the first 2 h after the burn

Model: Deep partial-thickness (second-degree) thermal burn

Glutathione mesotherapy produced the greatest healed burn area and best histopathological scores (P = 0.001 versus control and sham), ahead of taurine and L-carnitine, whose improvements were not statistically significant.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

PMID 24317693 ↗2013Reported benefit

Transcranial amelioration of inflammation and cell death after brain injury.

MixedTBIClosed-head / concussionC57BL/6J, CX3CR1-GFP, FVB/N-Tg(GFAP-GFP)14Mes/J and LysM-GFP mice; Sprague-Dawley ratsMale (rats); not reported for micen = Group sizes of 3-4 rodents per experiment, each experiment…Transcranial topical application to the intact or thinned skull bone, and addition to the aCSF submerging solution100 mM glutathione in artificial cerebrospinal fluid30 min before injury (pre-treatment), or continuously from 15 min or 3 h after…

Model: Novel closed-skull compression brain injury produced by rapidly thinning the skull over the barrel cortex to approximately 20-30 micrometres and gently pressing it into concavity; a skull fracture variant was used as a more severe injury

Transcranial glutathione given before injury allowed near complete survival of meningeal macrophages after skull fracture, preserved the glial limitans, kept underlying microglia ramified and non-reactive, and eliminated myelomonocytic recruitment. Pre-treatment reduced meningeal cell death by 50%,…

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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