THERAPY DOSSIER · th-26f412093a70

Neurally induced bone marrow derived mesenchymal stem cells (NIMSC), compared with olfactory ensheathing cells (OEC)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03933072 ↗Injury indicationPHASE1/PHASE2unknown

Functional Axon Regeneration in Complete Spinal Cord Injury Using Autologous Bulbar Olfactory Ensheathing Cells and Spinal Cord Bridging

Spinal Cord Injury C5-Th10 Complete Lesion · Spinal Cord Transection

Enrolment: 2 · Results not recorded

NCT01231893 ↗Injury indicationPHASE1unknown

Transplantation of Autologous Olfactory Ensheathing Cells for Complete Human Spinal Cord Injuries: Phase I

Complete Spinal Cord Injuries

Enrolment: 10 · Results not recorded

NCT02870426 ↗Injury indicationPhase not recordedunknown

Collection and Characterisation of Human Olfactory Ensheathing Cells

Spinal Cord Injury

Enrolment: 50 · Results not recorded

NCT01327768 ↗PHASE1unknown

Safety, Feasibility and Treatment Potential for Old Stroke Patients Using Intracerebral Implantation of Olfactory Ensheathing Cells

Middle Cerebral Artery Infarction · Ischaemic Stroke

Enrolment: 6 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22551686 ↗2012Reported benefit

A comparison between neurally induced bone marrow derived mesenchymal stem cells and olfactory ensheathing glial cells to repair spinal cord injuries in rat.

RatSpinal cord injuryCompressionWistarFemaleIntraparenchymal injection at the centre of the lesion cavity and 3 mm cranial and 3 mm caudal to itOne week after injury (sub-acute)

Model: Balloon-compression spinal cord injury at T8-T9

NIMSC produced significantly better locomotor recovery than OEC and control groups, significantly less syrinx cavity volume than controls, and higher neurofilament-positive axon expression.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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