THERAPY DOSSIER · th-26933a2ae6d0

High-frequency epidural spinal cord stimulation (HF-ES)

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06230120 ↗PHASE2completed

A Sham-Controlled, Randomized Trial of Spinal Cord Stimulation for the Treatment of Pain in Chronic Pancreatitis

Chronic Pancreatitis · Chronic Pain

Enrolment: 16 · Results not recorded

NCT04157400 ↗NAcompleted

Neuromodulation of Motor and Sensory Spinal Pathways in Subjects Undergoing Epidural Spinal Cord Stimulation

Chronic Pain

Enrolment: 5 · Results not recorded

NCT03543085 ↗NAcompleted

Ultra-high Frequency (500 KHz) Spinal Cord Stimulation for Treatment of Chronic Back Pain or Lower Limb Pain

Pain, Chronic · Pain, Back · Pain, Radiating

Enrolment: 10 · Results not recorded

NCT03769675 ↗NAcompleted

Quantitative Assessment of Painful Diabetic Peripheral Neuropathy After High Frequency Spinal Cord Stimulation (QUANT) HF10 Study

Painful Diabetic Neuropathy

Enrolment: 10 · Results not recorded

NCT04582721 ↗NAunknown

PREFerred Neurostimulation MODdalities to Treat Chronic Intractable Back Pain, A 3x3 Crossover Study

Chronic Low-back Pain

Enrolment: 18 · Results not recorded

NCT06272539 ↗NAcompleted

Spinal Cord Stimulation Combined With Exercise in Patients Diagnosed With Persistent Spinal Pain Syndrome (RCT)

Failed Back Surgery Syndrome

Enrolment: 36 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28615341 ↗2017Mixed findings

High-frequency epidural stimulation across the respiratory cycle evokes phrenic short-term potentiation after incomplete cervical spinal cord injury.

RatSpinal cord injuryHemisection / partialSprague-DawleyFemaleEpidural stimulation of the ventrolateral spinal cord at C4 or T2, ipsilateral to the hemisection300 Hz stimulation, currents 100-1,000 microA2 weeks and 12 weeks after C2 hemisection

Model: C2 lateral spinal hemisection (C2Hx) producing ipsilateral hemidiaphragm paralysis, studied at 2 wk (subacute) and 12 wk (chronic) post-injury

HF-ES potentiated ipsilateral phasic phrenic output (T2 stimulation at both 2 and 12 wk; C4 stimulation only at 12 wk), but also drove tonic phrenic output to about 500% of baseline, so the continuous 60 s paradigm was judged unsuitable for respiratory muscle activation.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.

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