THERAPY DOSSIER · th-25cde9073ada

Exercise (activity-based training)

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02098564 ↗Injury indicationNAcompleted

The Effect of Activity-based Training in Patients With Hand-related Injuries Grouped Using Sense of Coherence Scores

Hand Related Injuries

Enrolment: 504 · Results not recorded

NCT05472584 ↗Injury indicationNArecruiting

Neural Plasticity by Spinal Cord Stimulation and Training in People With Spinal Cord Injury

Spinal Cord Injuries

Enrolment: 120 · Results not recorded

NCT06564597 ↗NAcompleted

Effectiveness of Activity-based Training After Myocardial Infarction: A Randomized Controlled Study

Myocardial Ischemia · Activities of Daily Living

Enrolment: 42 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24990918 ↗2014Reported benefit

Exercise modulates chloride homeostasis after spinal cord injury.

RatSpinal cord injuryComplete transectionSprague DawleyFemaleApplied after transection in the SCI-14d plus exercise and SCI-28d plus exercis…

Model: Complete spinal cord transection at T12

Exercise returned spinal excitability and KCC2 and NKCC1 levels towards normal in the lumbar spinal cord. Blocking KCC2 with DIOA masked the effect of exercise on frequency-dependent depression, while bumetanide returned FDD towards intact levels after injury.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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