Xyloketal derivative C53N protects against mild traumatic brain injury in mice.
MouseTBIClosed-head / concussionC57BL/6Malen = Four groups, n=5-7 per groupIntraperitoneal, solubilised in 0.5% dimethyl sulfoxide in saline40 or 100 mg/kg1 h after injury
Model: Closed-skull mild traumatic brain injury created by thinning a 2.0 x 2.0 mm cranial window over the left somatosensory cortex to 20-30 um and pressing the pliable bone downward 0.5 mm
C53N at 40 or 100 mg/kg given 1 h after injury reduced parenchymal cell death at 6 and 12 h, lesion size and brain water content at 24 h, lowered hydrogen peroxide and reduced glial reactivity.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.