Trial title not recorded
Pulmonary Disease, Chronic Obstructive
Enrolment: 213 · Results not recorded
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Drug · Muscarinic acetylcholine receptor M3 antagonist (ANTAGONIST; direct interaction)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Pulmonary Disease, Chronic Obstructive
Enrolment: 213 · Results not recorded
Pulmonary Disease, Chronic Obstructive · Chronic Bronchitis · Pulmonary Emphysema
Enrolment: 33 · Results not recorded
Chronic Obstructive Pulmonary Disease
Enrolment: 509 · Results not recorded
Chronic Obstructive Pulmonary Disease (COPD)
Enrolment: 160 · Results not recorded
COPD
Enrolment: 79 · Results not recorded
Chronic Obstructive Pulmonary Disease
Enrolment: 140 · Results not recorded
Healthy
Enrolment: 36 · Results not recorded
Healthy
Enrolment: 56 · Results not recorded
COPD
Enrolment: 407 · Results not recorded
Pulmonary Disease, Chronic Obstructive
Enrolment: 95 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Cadmium inhalation-induced acute neutrophilic pulmonary inflammation using nebulised 0.1% cadmium chloride solution for 60 minutes in an exposure chamber
Tiotropium reduced lavage cell counts, protein and histological injury and lowered MMP-2 at the high concentration, and the combination with budesonide significantly reduced airway hyperresponsiveness (Emax 2.19 plus or minus 0.39 g versus 4.08 plus or minus 0.42 g for cadmium alone) and inhibited…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.