Effect of platelet-activating factor and its receptor antagonist, SRI 63-675, on gastric bleeding in rats.
RatWoundInbred strain not specifiedIntravenous infusionPAF 25 ng/kg/min; SRI 63-675 50 micrograms/kg/minDuring the 2 h bleeding observation period after mucosal wounding
Model: Induced gastric mucosal wound with haemostasis mechanically disturbed by saline perfusion of the lesion, monitored for 2 h
Intravenous PAF at 25 ng/kg/min reduced blood loss from the perfused gastric mucosal wound by 92% without changing the bleeding pattern or macroscopic mucosal appearance. SRI 63-675 at 50 micrograms/kg/min completely reversed this effect, but given alone did not change bleeding, suggesting endogeno…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.