The gastroprotective effects of hydroalcoholic extract of Monolluma quadrangula against ethanol-induced gastric mucosal injuries in Sprague Dawley rats.
RatChemical/toxinSprague Dawleymalen = 24 male rats in the ulcer study, six per group in five grou…oral150 or 300 mg/kg (dosing volume 5 mL/kg)1 h before oral absolute ethanol
Model: Acute gastric mucosal injury induced by oral absolute ethanol 5 mL/kg after a 24 h fast
Pretreatment reduced gastric mucosal lesion area by 60.93 per cent at 150 mg/kg and 71.51 per cent at 300 mg/kg, raised gastric pH and wall mucus, preserved mucosal histology and glycoprotein staining, increased superoxide dismutase and catalase and lowered malondialdehyde, with upregulation of Hsp…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.