THERAPY DOSSIER · th-218be80f0e9f

Plasmid DNA encoding the alpha and beta subunits of the Na+/K+-ATPase pump, delivered by electroporation

Other

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Crush
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01138410 ↗PHASE1/PHASE2terminated

SCIB1 DNA immunotherapy delivered by electroporation in malignant melanoma

Malignant Melanoma

Enrolment: 35 · Results not recorded

NCT00685412 ↗PHASE1completed

VGX-3100 HPV DNA plasmid plus electroporation after treatment of CIN 2/3

Papillomavirus Infections

Enrolment: 18 · Results not recorded

NCT01578889 ↗PHASE1completed

IL-12 pDNA enhanced HIV-1 multiantigen pDNA vaccine delivered intramuscularly with electroporation

HIV Infections

Enrolment: 100 · Results not recorded

NCT02531425 ↗PHASE1completed

Intratumoral plasmid IL-12 electroporation in triple negative breast cancer

ER-negative PR-negative HER2-negative Breast Cancer

Enrolment: 10 · Results not recorded

NCT04627675 ↗PHASE1terminated

CORVax12 SARS-CoV-2 spike plasmid DNA vaccine +/- pIL-12 with Cliniporator electroporation

SARS-CoV-2

Enrolment: 16 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 22310113 ↗2012Reported benefit

Electroporation-mediated in vivo gene delivery of the Na+/K+-ATPase pump reduced lung injury in a mouse model of lung contusion.

MouseCrushOther / unspecifiedC57BL/6malen = n=9 per group at each of 24, 48 and 72 h plus 9 naive contr…intratracheal instillation followed by transthoracic electroporation100 micrograms plasmid DNA in 100 mM NaCl; electroporation…within several minutes after lung contusion, under the same anaesthetic

Model: unilateral lung contusion produced by a cortical contusion impactor striking the right chest 1 cm above the costal margin along the posterior axillary line (piston velocity 5.8 m/s, depth 10 mm)

Gene delivery of the Na+/K+-ATPase subunits immediately after contusion reduced BAL albumin, improved compliance and hysteresis at 24, 48 and 72 h and lessened alveolar inflammation on histology.

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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