THERAPY DOSSIER · th-20c78432b113

Soybean trypsin inhibitor, lima bean trypsin inhibitor, antipain, alpha-N-benzoyl-L-arginine ethyl ester hydrochloride, trasylol (aprotinin), leupeptin

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 7040272 ↗1982Mixed findings

gamma-Irradiation-induced mortality: protective effect of protease inhibitors in chickens and mice.

MouseRadiationBALB/c and SJL/J miceMale and female

Model: Acute whole-body gamma irradiation causing mortality within 24 hours in chickens and within the first week in mice, at 690 R in BALB/c and 880 R in SJL/J

Soybean and lima bean trypsin inhibitors, antipain, BAEE, trasylol and leupeptin protected chickens against acute irradiation mortality within 24 hours, and soybean trypsin inhibitor and antipain also protected BALB/c and SJL/J mice at 690 R and 880 R respectively. TAME and TLCK did not protect and…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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