Silencing of fas, fas-associated via death domain, or caspase 3 differentially affects lung inflammation, apoptosis, and development of trauma-induced septic acute lung injury.
MouseOtherC57Bl/6MaleIntratracheal administration24 h before and 12 h after blunt chest trauma
Model: Blunt chest trauma followed 24 h later by polymicrobial sepsis induced by caecal ligation and puncture
Silencing of caspase 3 or FADD markedly reduced pulmonary apoptosis, Fas and FADD silencing decreased lung cytokine concentrations and Fas silencing decreased neutrophil infiltration, but only caspase 3 silencing substantially improved epithelial barrier dysfunction and histological appearance.
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