Enhanced antimicrobial and full-thickness wound healing efficiency of hydrogels loaded with heparinized ZnO nanoparticles: In vitro and in vivo evaluation.
RatWoundWistarmaleTopical implantation of the dressing on the wound
Model: Full-thickness skin wound in rats
Adding nanoparticles roughly doubled mechanical strength relative to the nanoparticle-free hydrogel and heparin release followed Hixson-Crowell kinetics. Conjugating heparin to the zinc oxide nanoparticles lowered the minimum inhibitory concentration relative to non-functionalised nanoparticles, in…
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