THERAPY DOSSIER · th-1d4b6c3d2a16

Fluid resuscitation with lactated Ringer's, plasma or very hypertonic saline (2,400 mosmol/l)

Procedure · Resuscitation procedure, not a ChEMBL-registered molecular entity, so resolved=false. Human evidence exists for the component fluids; trials listed are crystalloid/hypertonic resuscitation studies in shock and trauma.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Resuscitation procedure, not a ChEMBL-registered molecular entity, so resolved=false. Human evidence exists for the component fluids; trials listed are crystalloid/hypertonic resuscitation studies in shock and trauma.
Target: Not recorded
Injury models: Burn
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01692769 ↗Injury indicationPHASE4completed

Intravenous Fluid in Severely Injured Paediatric Trauma Patients: Normal Saline Versus Ringer's Lactate

Trauma

Enrolment: 50 · Results not recorded

NCT01433276 ↗Injury indicationPHASE3completed

Hypertonic Sodium Lactate (Totilac) Infusion for Resuscitation of Patients With Hemorrhagic Shock Due to Multiple Injuries

Hemorrhagic Shock

Enrolment: 71 · Results not recorded

NCT05559489 ↗Injury indicationPHASE3unknown

Implementation of an Enteral Resuscitation Bundle for the Moderate-sized Burn (Oral Rehydration Solution vs Lactated Ringer)

Burn Shock

Enrolment: 240 · Results not recorded

NCT00966628 ↗PHASE3unknown

Effect of Hypertonic Sodium Lactate on sVCAM-1 in Paediatric Dengue Shock Syndrome

Dengue Shock Syndrome

Enrolment: 50 · Results not recorded

NCT01713595 ↗PHASE1withdrawn

Inhaled Hypertonic Saline for the Treatment of Acute Lung Injury

Pulmonary Edema

Enrolment: 0 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 2917370 ↗1989Mixed findings

Thermal skin injury: I. Acute hemodynamic effects of fluid resuscitation with lactated Ringer's, plasma, and hypertonic saline (2,400 mosmol/l) in the rat.

RatBurnScaldInbred strain not specifiedFemaleIntravenousLactated Ringer's 5 ml/h; plasma 2.5 ml/h; hypertonic salin…Postburn

Model: 40% total body surface area full-thickness scald burn under anaesthesia

Cardiac index fell to 58-71% of control within 15 min of burn. Lactated Ringer's and plasma raised cardiac index to 74-80% of control and prevented the fall in mean arterial pressure seen in untreated burns (110 to 80 mmHg at 3 h), and limited haemoconcentration (haematocrit 48 to 52% versus 48 to…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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