Swim therapy reduces mechanical allodynia and thermal hyperalgesia induced by chronic constriction nerve injury in rats.
RatOtherSprague-DawleyMalen = 6 rats per group in each of 4 groups (24 total)Whole-body exercise (not applicable)One hour of continuous swimming per session in water at 34…Two-week graded swim training before nerve constriction; after surgery rats rec…
Model: Chronic constriction injury of the right sciatic nerve (four loose chromic gut 4-0 ligatures at 1 mm intervals proximal to the sciatic trifurcation, modified Bennett and Xie method)
Chronic constriction injury produced stable mechanical allodynia and thermal hyperalgesia in the ipsilateral paw. Regular swim therapy significantly raised normalised mechanical and thermal withdrawal thresholds compared with the no-swim injured group on most testing days, although thresholds remai…
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