Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Wound
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 10
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Phase I, Double-Blind, Randomized, Controlled Study to Demonstrate the Safety of Applying Autologous Platelet Rich Plasma (PRP) Gel (Magellan Bio-Bandage) to Acute Deep Partial Thickness Thermal Injuries
Acute Deep Partial Thickness Thermal Burns
Enrolment: 36 · Results not recorded
Clinical Efficacy of Arthroscopic Microfracture Combined With Local Injection of Platelet Rich Plasma Gel in Treatment of Osteochondral Lesion of the Talus: A Randomized Control Trial
Osteochondral Lesion of Talus · Microfractures · Platelet Rich Plasma
Enrolment: 70 · Results not recorded
Effectiveness of Apheresis Platelet-Rich Plasma Injection for Androgenic Alopecia: A Single-Arm Trial
Androgenic Alopecia
Enrolment: 201 · Results not recorded
Effect of Autologous Platelet-rich Plasma on Photoaged Skin: A Prospective Randomized Controlled Trial (Phases A and B)
Photoaging
Enrolment: 23 · Results not recorded
Autologous Platelet Rich Plasma Intradermal Injections for Vulvar Lichen Sclerosus
Lichen Sclerosus
Enrolment: 15 · Results not recorded
Comparison of Acetaminophen and Platelet-rich Plasma Therapy for the Treatment of Knee Osteoarthritis.
Knee Osteoarthritis
Enrolment: 543 · Results not recorded
Autologous Platelet-rich Plasma (APRP) in the Treatment of Neurotrophic Keratopathy
Neurotrophic Keratopathy
Enrolment: 39 · Results not recorded
Structural Evaluation of Human Melanocytes After the Use of Autologous Platelet-rich Plasma (PRP) Versus Fractional Carbon Dioxide Laser (Fr:CO2 Laser) in Treatment of Vitiligo
Vitiligo
Enrolment: 30 · Results not recorded
The Effect of Injectable Platelet Rich Derivatives on the Rate of Orthodontic Canine Retraction: A Split-Mouth Randomized Controlled Trial
Accelerate Tooth Movement
Enrolment: 21 · Results not recorded
Evaluation of Combined Photo-Biomodulation At Acupuncture Points, Autologous PRP, and Umbilical Cord-Derived Exosome Therapy in Autism Spectrum Disorder: a Randomized Controlled Trial
Autism Spectrum Disorder
Enrolment: 100 · Results not recorded
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
MouseWoundC57BL/6Malen = 40 mice randomised to saline control and PRP groupsLocal injection into the wound100 microlitres activated PRP per woundImmediately after wounding
Model: Two 6 mm circular full-thickness dorsal excisional wounds
PRP accelerated wound closure, reduced IL-17A and IL-1 beta, increased angiogenesis and re-epithelialisation, and enhanced epidermal stem cell survival and migration relative to saline.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
RatWoundWistarMalen = 44 Wistar rats in two groups, with 12 rats per group for bi…Intra-articular injection into the shoulderSingle dose, volume not statedImmediately after the surgical repair
Model: Experimental acute rotator cuff tear with surgical suture repair, assessed at 3 weeks
Platelet-rich plasma increased maximal load (p < 0.001) and stiffness (p < 0.005), improved Bonar score (p = 0.018) and collagen organisation by birefringence (p = 0.002) at 3 weeks, with no difference in vascularity.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
