THERAPY DOSSIER · th-1765549c362e

Locomotor exercise training

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 10

3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03979742 ↗Injury indicationPHASE2terminated

Umbilical Cord Blood Cell Transplant Followed by Locomotor Training for Chronic Complete SCI

Spinal Cord Injuries

Enrolment: 6 · Results not recorded

NCT01147185 ↗Injury indicationNAcompleted

Automated Locomotor Training in Patients With Acute Incomplete Spinal Cord Injury

Spinal Cord Injuries

Enrolment: 21 · Results not recorded

NCT00854555 ↗Injury indicationNAcompleted

The ATLET Study: Can Subjects With Incomplete Spinal Cord Injury Learn to Walk?

Spinal Cord Injury

Enrolment: 44 · Results not recorded

NCT02435667 ↗NAcompleted

Resistance Exercise Training in Heart Failure With Preserved Ejection Fraction

Heart Failure Preserved Ejection Fraction

Enrolment: 24 · Results not recorded

NCT02787759 ↗NAcompleted

Falls-based Training to Improve Balance and Mobility Post-Stroke

Cerebral Hemiplegia

Enrolment: 54 · Results not recorded

NCT01435694 ↗NAcompleted

Robot-assisted Gait Training on Locomotor Function in Multiple Sclerosis

Multiple Sclerosis

Enrolment: 60 · Results not recorded

NCT03566901 ↗NAunknown

Robot-assisted Locomotor and Stair Climbing Training in Persons Affected by Stroke

Stroke

Enrolment: 72 · Results not recorded

NCT02266004 ↗NAterminated

Transcranial Direct Current Stimulation for Freezing of Gait in Parkinson's Disease

Parkinson's Disease

Enrolment: 9 · Results not recorded

NCT03864393 ↗NAcompleted

12-week Multimodal Exercise Intervention on Walking Economy in Parkinson's Disease

Parkinson Disease

Enrolment: 17 · Results not recorded

NCT05720013 ↗NAcompleted

Acute Effects of Beetroot Juice on Locomotor Economy and Capacity in Chronic Stroke

Stroke · CVA

Enrolment: 22 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 21242998 ↗2011Reported benefit

Exercise therapy and recovery after SCI: evidence that shows early intervention improves recovery of function.

RatSpinal cord injuryContusionSprague-DawleyMale60 min per dayInitiated day 1 (acute) versus day 8 (secondary phase)

Model: Moderate spinal contusion injury

Exercise started on day 1 improved locomotor recovery and reduced tissue damage more than day 8 initiation, indicating early intervention maximises recovery.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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