THERAPY DOSSIER · th-15ce66b0be2c

Sodium pyrophosphate (inorganic pyrophosphate, PPi)

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL450079 ↗
ChEMBL max phase: -1 / 4 (development scale, not regulatory approval)
Synonyms: Sodium pyrophosphate; Tetrasodium pyrophosphate
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04441671 ↗PHASE2withdrawn

Oral Disodium Pyrophosphate (Na2H2PPi) Absorption in Pseudoxanthoma Elasticum (PXE)

Pseudoxanthoma Elasticum

Enrolment: 0 · Results not recorded

NCT04966416 ↗NAunknown

The Effect of Orally Administered Pyrophosphate on Calcinosis Formation in Systemic Sclerosis

Systemic Sclerosis · Scleroderma

Enrolment: 60 · Results not recorded

NCT04238429 ↗NAcompleted

Efficacy of a Dentifrice Containing 0.5% Sodium Pyrophosphate on Tooth Whitening

Tooth Bleaching

Enrolment: 86 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32885586 ↗2020Reported benefit

Pyrophosphate therapy prevents trauma-induced calcification in the mouse model of neurogenic heterotopic ossification.

MouseTBIWeight-drop / impact-accelerationCD1 (main experiments); model also validated in C57BL/6J and Balb/CFemaleIntraperitoneal injection combined with oral administration in drinking water80-100 mg/kg sodium pyrophosphate per intraperitoneal injec…First intraperitoneal dose given immediately (within 1 min) after TBI + CTX or…

Model: Combined polytrauma model of neurogenic heterotopic ossification: weight-drop traumatic brain injury plus cardiotoxin-induced hamstring muscle injury (TBI + CTX); adrenaline plus cardiotoxin (ADR + CTX) used as an alternative model

Combined pyrophosphate treatment starting immediately after injury reduced calcified deposit volume in the hamstring muscle from 5.25 to 0.11 mm3 (p = 0.02), and starting 30 min after injury from 5.25 to 0.08 mm3 (p = 0.03). In the adrenaline plus cardiotoxin model, calcification fell from 3.04 to…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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