THERAPY DOSSIER · th-1540fa22a002

Chitosan porous 3D scaffold embedded with resolvin D1

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Fracture
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04496570 ↗NAcompleted

The Role of Resolvin D1 in Maintaining Oral Health

Periodontitis

Enrolment: 26 · Results not recorded

NCT04997057 ↗NAcompleted

Effect of a Mixture of Probiotics (Lactibiane Reference) in Patients With Irritable Bowel Syndrome Predominantly Constipation and Assessment of a Potential Biomarker (Resolvin D1): an Exploratory Study

Irritable Bowel Syndrome With Constipation

Enrolment: 80 · Results not recorded

NCT03483311 ↗NAunknown

Estimation of Tissue Level of Resolvin D1 in Psoriasis Before and After Narrowband UVB Phototherapy: a Case-control Study

Psoriasis

Enrolment: 30 · Results not recorded

NCT07353970 ↗Phase not recordednot yet recruiting

Mechanisms of Prognostic Regulation and Precision Phenotype Identification in Severe Infections Driven by Specialized Pro-Resolving Mediators

Sepsis · Severe Infection · Multiple Organ Dysfunction Syndrome · Critical Illness

Enrolment: 300 · Results not recorded

NCT06652464 ↗Phase not recordedcompleted

The Relationship Between Maresin-1 and Resolvin-D1 Levels and Disease Activity in Ulcerative Colitis

Disease Activity · Remission of Ulcerative Colitis · Ulcerative Colitis Flare

Enrolment: 90 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 29453815 ↗2018Reported benefit

Chitosan porous 3D scaffolds embedded with resolvin D1 to improve in vivo bone healing.

RatFractureFemurWistarMaleImplantation into the femoral defectAt the time of defect creation

Model: Rat femoral bone defect with scaffold implantation

Two months after implantation, chitosan scaffolds embedded with resolvin D1 increased new bone formation, trabecular thickness, collagen type I and the collagen I to collagen III ratio compared with chitosan scaffolds alone, indicating that pro-resolving mediator delivery during the acute inflammat…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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