THERAPY DOSSIER · th-1376b6337aee

Oxandrolone, a testosterone analogue

Hormone · Synthetic anabolic androgenic steroid (androgen receptor agonist); no ChEMBL mechanism record.

No trauma translation Suggest a correction

This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Synthetic anabolic androgenic steroid (androgen receptor agonist); no ChEMBL mechanism record.
Target: Not recorded
Injury models: Burn · Spinal cord injury
Reported indication: Not recorded
First approval: 1964
Development stage: Not recorded
ChEMBL record: CHEMBL1200436 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Anavar; Oxandrin; SC-11585
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05893069 ↗PHASE4suspended

Oral Oxandrolone in Rehabilitation of Multiligament Knee Reconstructions

Ligament Tear Knee

Enrolment: 60 · Results not recorded

NCT00001343 ↗PHASE2completed

Androgen/Estrogen (incl Oxandrolone) in GH-Treated Turner Syndrome

Turner's Syndrome

Enrolment: 80 · Results not recorded

NCT00027391 ↗NAcompleted

Albuterol and Oxandrolone in FSH Dystrophy

Muscular Dystrophies

Enrolment: 160 · Results not recorded

Preclinical evidence 2

1 studies reported at therapy level; 2 evidence entries itemised.

PMID 31053861 ↗2019No effect reported

Investigation into Possible Association of Oxandrolone and Heterotopic Ossification Following Burn Injury.

MixedBurnUnspecifiedAdministered after burn in the clinical cohort, with postburn day of initiation…

Model: Retrospective cohort of acutely burned adults admitted to a single burn centre between 2000 and 2014 with a heterotopic ossification risk factor score of 7 or higher, together with a standardised mouse burn plus tenotomy model of trauma-related heterotopic ossification

Patients who received oxandrolone had a higher crude incidence of elbow heterotopic ossification, but after adjustment for oxandrolone administration and duration, postburn day of initiation, heterotopic ossification risk score category, age, sex, race, burn size and year of injury there was no sig…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

PMID 19424096 ↗2009

Improved functional recovery with oxandrolone after spinal cord injury in rats

RatSpinal cord injury

Extraction: mesh. Machine-extracted fields require source verification.

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