Resolution mediator chemerin15 reprograms the wound microenvironment to promote repair and reduce scarring.
MouseWoundSv129Ev wild-type and ChemR23-deficient mice for excisional wounding; C57Bl6/J for intravital imagingTopical into the wound cavity; intradermal for the burn imaging model100 pg per wound in 40 microlitres of 30% Pluronic F-127 ge…Immediately after wounding
Model: Four full-thickness excisional wounds made with a 4 mm biopsy punch on shaved dorsal skin, removing epidermis, dermis and panniculus carnosus; small cutaneous burn wounds used for intravital imaging
C15 accelerated wound closure (36% versus 70% of starting size at day 4) and earlier scab loss, cut neutrophil numbers by 68% and neutrophil adhesion by 74% at 2 h, and reduced collagen fibre alignment from 0.90 to 0.71 versus 0.57 in unwounded skin, indicating less scarring.
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.