SPA0355 attenuates ischemia/reperfusion-induced liver injury in mice.
Model: Partial warm hepatic ischaemia-reperfusion: an atraumatic clip placed across the portal vein, hepatic artery and bile duct above the right branch interrupted blood flow to the left lateral and median lobes (about 70% of hepatic blood supply) for 45 min, followed by reperfusion (nuclear extracts at 1 h, prothrombin time at 6 h, injury and histology at 24 h)
Pretreatment reduced ischaemia-reperfusion induced transaminase elevation dose-dependently (2.5 µg/kg reduced AST by 19.6% and ALT by 21.3%; 5 µg/kg reduced AST by 60.8% and ALT by 59.2%, with no further gain at 10 µg/kg), shortened the prolonged prothrombin time at 6 h, preserved liver architectur…
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