THERAPY DOSSIER · th-0f01c9af7aa4

Cobalt protoporphyrin (CoPP)

Drug · ChEMBL compound_search 'cobalt protoporphyrin' returned 0 hits: an EXPLICIT NEGATIVE RESULT, not an omission. ClinicalTrials.gov intervention search 'cobalt protoporphyrin OR heme oxygenase-1 inducer' returned 0 trials, also an explicit zero. CoPP is a metalloporphyrin HO-1 inducer used only as a preclinical tool; no human trial administers it. to_trial=false by search, not by assumption.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: ChEMBL compound_search 'cobalt protoporphyrin' returned 0 hits: an EXPLICIT NEGATIVE RESULT, not an omission. ClinicalTrials.gov intervention search 'cobalt protoporphyrin OR heme oxygenase-1 inducer' returned 0 trials, also an explicit zero. CoPP is a metalloporphyrin HO-1 inducer used only as a preclinical tool; no human trial administers it. to_trial=false by search, not by assumption.
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26070773 ↗2015Reported benefit

Can Cytoprotective Cobalt Protoporphyrin Protect Skeletal Muscle and Muscle-derived Stem Cells From Ischemic Injury?

MouseIschaemia-reperfusionLimb / skeletal muscleC57BL/6n = 7 mice per group in three post-injury treatment groups, plu…Intraperitoneal (in vivo); 25 microM single exposure in vitroAdministered during ischaemia, at the onset of reperfusion, or 1 h after reperf…

Model: Unilateral hindlimb ischaemia produced by 2 h tourniquet application followed by 24 h reperfusion; parallel in vitro hypoxia (5 h, <0.5% O2) and 24 h reoxygenation of muscle-derived stem cells

CoPP given during ischaemia reduced gastrocnemius myocyte damage by 38% (86.4% to 53.2% Evans blue positive fibres, p<0.001) and by 30% when given at reperfusion onset; tibialis anterior damage fell 27% only with dosing at reperfusion onset. Delaying to 1 h after tourniquet release abolished protec…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

Loading the evidence…

Cobalt protoporphyrin (CoPP)