Acute spinal cord injury is associated with mitochondrial dysfunction in mouse urothelium.
MouseSpinal cord injuryComplete transectionC57Bl/6femalesubcutaneous osmotic minipump (Alzet 1007D)1 mg/kg/day in 0.9% salinePump implanted at the time of injury
Model: Complete spinal cord transection between T8 and T9 vertebrae after laminectomy under isoflurane; bladders manually voided twice daily; tissue collected 3 days after injury
MitoTempo lowered nitrotyrosine, reduced or eliminated aberrant mitochondrial inclusions and increased autolysosomes, although apoptotic markers and DRP1 only trended towards normal.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.