The Utility of Silk-elastin Hydrogel as a New Material for Wound Healing.
MixedWoundGenetically diabetic mice (C57BLKS/J Iar+Lepr db/+Lepr db); Hartley (std:Hartley) guinea pigsFemalen = 120 female diabetic mice (n = 30 per group across silk-elas…Topical, implanted into the wound and covered with polyurethane film56 microlitres per animal of 20% (w/v) aqueous silk-elastin…Applied immediately after wound creation
Model: Full-thickness skin defect 12 mm in diameter on the back of diabetic mice (chronic ulcer model) and 8 mm full-thickness defect within a 10 mm tattooed ring on the back of healthy guinea pigs (acute ulcer model)
In diabetic mice at 14 days the silk-elastin group showed a significantly higher epithelialisation rate than all other groups (about 1.5-fold) and a significantly larger granulation tissue area than control and Intrasite gel groups; at 21 days epithelialisation remained higher than control and Intr…
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