THERAPY DOSSIER · th-09d8fcd80c52

Human umbilical cord derived mesenchymal stem cells, expanded in vitro

Biologic · Cell therapy (umbilical cord-derived MSCs); not a ChEMBL entity

Evidence & regulatory context

Mechanism: Cell therapy (umbilical cord-derived MSCs); not a ChEMBL entity
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01873547 ↗Injury indicationPHASE3completed

Rehabilitation vs Umbilical Cord MSC Transplantation in Chronic Spinal Cord Injury

Spinal Cord Injury

Enrolment: 300 · Results not recorded

NCT05887804 ↗PHASE4completed

Intralesional UC-MSC, Its Conditioned Medium, and Triamcinolone as Keloid Therapy

Keloid

Enrolment: 24 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24144029 ↗2013Reported benefit

An experimental study of preventing and treating acute radioactive enteritis with human umbilical cord mesenchymal stem cells

RatRadiationWistarMaleIntravenous injection via the tail veinA prevention group and a treatment group, implying dosing before and after irra…

Model: Acute radioactive enteritis induced by irradiation in rats

Rats in the prevention and treatment groups had markedly better survival status than controls, and histology showed better preserved intestinal mucosal structure, more regenerative cells and greater proliferative activity. No quantitative effect sizes are given.

Extraction: extract · Supplied extraction confidence: 0.42. Machine-extracted fields require source verification.

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