THERAPY DOSSIER · th-05c4b08305a0

Chitosan gel matrix

Device · Device (chitosan gel matrix); not a ChEMBL entity; no clearly matching chitosan-gel trial identified

Evidence & regulatory context

Mechanism: Device (chitosan gel matrix); not a ChEMBL entity; no clearly matching chitosan-gel trial identified
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25950535 ↗2015Reported benefit

Enhancement of acute tendon repair using chitosan matrix.

RatOtherWistarn = 40 Wistar rats, bilateral shoulders (80 repairs)Local application of gel between the tendon ends at the repair siteAt the time of acute repair

Model: Bilateral supraspinatus tendon tenotomy followed by acute suture repair in rats

Gel-augmented repairs showed more fibroblasts and repair tissue, minimal monocytic or inflammatory infiltrate around the matrix, and significantly improved pennation angles and fatty atrophy compared with suture-only controls.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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