THERAPY DOSSIER · th-05165f3adabf

Angiotensin-(1-7)

Hormone · Proto-oncogene Mas agonist (pharmaceutical-grade formulation of endogenous ligand)

Evidence & regulatory context

Mechanism: Proto-oncogene Mas agonist (pharmaceutical-grade formulation of endogenous ligand)
Target: CHEMBL3559701
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL3545347 ↗
ChEMBL max phase: 2 / 4 (development scale, not regulatory approval)
Synonyms: Angiotensin-(1-7); Ang-(1-7); TXA127; Talfirastide; Angiotensin 1-7
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01882374 ↗PHASE2withdrawn

Phase II Evaluation of TXA127 (Angiotensin 1-7) to Reduce Acute GvHD in Double Umbilical Cord Blood Transplantation

Hematologic Malignancies

Enrolment: 0 · Results not recorded

NCT01553539 ↗PHASE2completed

Phase II Trial of Angiotensin 1-7 for Second/Third Line Treatment of Metastatic or Unresectable Sarcomas

Recurrent Adult Soft Tissue Sarcoma · Osteosarcoma · Uterine Sarcoma

Enrolment: 20 · Results not recorded

NCT04605887 ↗PHASE2unknown

Angiotensin 1-7 as a Therapy for Pneumonia Caused by SARS-CoV-2

COVID-19

Enrolment: 120 · Results not recorded

NCT03489993 ↗Phase not recordedcompleted

Interplay of FGF23 and Angiotensin-(1-7) in Hypophosphatemia (GAP)

Hypophosphatemia · X-linked Hypophosphatemia · Renin-angiotensin System

Enrolment: 8 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32658081 ↗2020Reported benefit

Angiotensin-(1-7) Treatment Restores Pancreatic Microcirculation Profiles: A New Story in Acute Pancreatitis.

MouseChemical/toxinC57BL/6Male

Model: Acute pancreatitis induced by intraperitoneal injection of cerulein plus lipopolysaccharide

Acute pancreatitis mice showed pancreatic injury with reduced blood distribution pattern, average blood perfusion, relative velocity, effective frequency and amplitude of microvascular vasomotion. Angiotensin-(1-7) significantly alleviated pancreatic pathological injury, restored microcirculation p…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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