Evidence of gastric ulcer healing activity of Maytenus robusta Reissek: In vitro and in vivo studies.
RatChemical/toxinWistarFemalen = 6 animals per groupOral (intraduodenal for the pylorus ligature model)1 to 10 mg/kg orally in vivo; 1 to 1000 micrograms/ml in vi…Treatment started after ulcer induction (healing rather than preventive protoco…
Model: Chronic gastric ulcer induced in rats by serosal application of 80% acetic acid; pylorus ligature model used for antisecretory assessment; gastrointestinal motility assessed in mice
Oral HEMR at 10 mg/kg reduced gastric ulcer area by 53% relative to the vehicle group (120.0 plus or minus 8.3 square millimetres), increased gastric mucin, and reduced oxidative and inflammatory markers at the ulcer site. It did not alter gastric secretion, gastrointestinal motility or Helicobacte…
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