Treatment of nonunion of limb fracture with human amniotic epithelial cells (hAECs)
Nonunion Fracture
Enrolment: 36 · Results not recorded
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Biologic
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Nonunion Fracture
Enrolment: 36 · Results not recorded
Spastic Cerebral Palsy
Enrolment: 10 · Results not recorded
Acute Graft Versus Host Disease
Enrolment: 0 · Results not recorded
Idiopathic Parkinson's Disease
Enrolment: 18 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Bronchopulmonary dysplasia model combining intra-amniotic lipopolysaccharide 0.1 ug in 5 ul per sac at embryonic day 16 with postnatal hyperoxia at FiO2 0.65 begun within 12 h of birth or at postnatal day 3.5, for 7, 14 or 28 days
A single dose of human amnion epithelial cells improved lung tissue-to-airspace ratio dose-dependently, with 75,000 and 100,000 cells effective by postnatal day 7, and intravenous and intratracheal routes were equally efficacious. Early and late treatment both restored septal crest density, lowered…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Bleomycin-induced lung injury and fibrosis
Human amnion epithelial cells given 14 days after bleomycin normalised lung tissue density, collagen content and alpha-smooth muscle actin production, whereas administration at 7 days had no effect on lung injury.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.