Increased severity of closed head injury or repetitive subconcussive head impacts enhances post-traumatic headache-like behaviors in a rat model.
RatTBIWeight-drop / impact-accelerationSprague DawleyMalen = Total n = 138 adult male Sprague Dawley ratsSystemic administration, route not further specified30 mg/kgBegun immediately after the 450 g injury or after the third 150 g weight drop
Model: Diffuse closed head injury with a weight-drop device: single 450 g drop, single 150 g drop, or three successive 150 g drops 72 h apart, versus sham
Severe closed head injury and repetitive subconcussive impacts produced cephalic and extracephalic tactile pain hypersensitivity, and early prolonged anti-CGRP monoclonal antibody treatment inhibited the cephalic hypersensitivity in both models.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.78. Machine-extracted fields require source verification.