Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Radiation
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
RatRadiationn = 100 rats divided into five groups; 7 rats per group analyse…Intraperitoneal injection14.5 nM (0.00001 mg/kg)Two weeks prior to radiation in one group and two weeks after radiation in anot…
Model: Radiation-induced acute lung injury from a single whole thorax radiation dose of 18 Gy
Cerium oxide nanoparticles significantly decreased the incidence of tissue collapse and neutrophil aggregation in rats receiving nanoparticles before radiation compared with the radiation-only group. The authors concluded the nanoparticles show promise as a radioprotector.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
RatRadiationSprague-Dawleysingle intravitreal injectionpost-injury administration, while photoreceptor degeneration was ongoing
Model: Acute photoreceptor damage induced by exposure to high intensity light in albino rats
A single post-injury intravitreal injection of nanoceria persisted in the retina for a long period and retained neuroprotective activity against light-induced photoreceptor degeneration.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
