PRECLINICAL PUBLICATION · 1982

Biochemical markers in carbon-tetrachloride-and galactosamine-induced acute liver injuries: the effects of dihydroquinoline-type antioxidants.

Mouse / Chemical/toxin

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

MTDQ, 6,6-methylene-bis(2,2,4-trimethyl-1,2-dihydroquinoline), and MDS, 6,6-methylene-bis(2,2-dimethyl-4-methanesulphonic acid sodium-1,2-dihydroquinoline)

PMID 7150502 ↗1982Reported benefit

Biochemical markers in carbon-tetrachloride-and galactosamine-induced acute liver injuries: the effects of dihydroquinoline-type antioxidants.

MouseChemical/toxinCFLP

Model: Carbon tetrachloride-induced and galactosamine-induced acute liver injury

The lipid-soluble MTDQ prevented carbon tetrachloride-induced injury and the water-soluble MDS prevented galactosamine-induced injury, with disappearance or significant reduction of lipid degeneration and centrilobular necrosis, reduced serum GOT activity, and reduced galactosamine-induced inflamma…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.