Minimal surgical debridement for the treatment of chemotherapeutic agent-induced skin extravasations.
RatChemical/toxinfemaleSurgical excision at the injection siteDebridement at 1, 24 or 72 hours after injection; residual necrotic tissue rede…
Model: Bilateral flank injections of doxorubicin at a concentration comparable to that received by humans, producing skin ulcers
All minimal debridement and redebridement groups significantly reduced ulcer size compared with non-operated controls and reduced the number of persistent ulcers. Debridement followed by redebridement was significantly more effective than debridement alone at acutely reducing ulcer size. One patien…
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