Pharmacological investigations of the new antiinflammatory agent 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid. 3rd communication: inhibitory effects on leucocyte emigration and proliferation of granulation.
RatOthermale
Model: Carrageenin pleurisy, carboxymethylcellulose pouch, and paper disk granulation models of inflammation and granulation tissue formation
CN-100 inhibited protein exudation and polymorph emigration at 6 h and monocyte emigration at 24 h, with activity approximately equal to pranoprofen and weaker than indometacin. It also inhibited granulation tissue proliferation, that is it inhibited wound healing, again comparable to pranoprofen a…
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